Synthesis of Fluorinated Heterocyclic Compounds for Pharmacological Screening

A series of derivatives (E)-6-chloro-5-fluoro-2-styryl-1H-benzo[d]imidazole, and 5-fluoro-2-methylN-phenyl-1H-benzo[d]imidazol-6-amine was synthesized. Compounds confirmed by melting point, FT-IR, 1HNMR, Mass spectral analytical techniques predicted for their ADME, Pharmacokinetic properties.Synthesized compounds screened better antibacterial antiinflammatory activity. To synthesize a novel trisubstituted fluorinated benzimidazole evaluate the physicochemical, ADME pharmacokinetic properties biological The starting material Flouro-chloro-aniline ona reaction such as acetylation, nitration, deacetylation followed reductionto get 4-fluoro-5-chloroorthophenylene diamine. di-amino compound cyclized with acetyl chloride to obtain 6-chloro-5-fluoro-2- methyl-1H-benzimidazole which on various aromatic aldehyde forms 31(a-h), anilines 32(a-j). Physicochemical, Insilco. Antimicrobial activity Agar diffusion method. In vitro protein denaturation assay.The synthesized Point, in silico. moderate antimicrobial,